Neurological soft signs in adolescents with first episode psychosis.
نویسندگان
چکیده
The purpose of this study is to determine the decrease of neurological soft signs (NSS) during adolescence and to compare this evolutionary process in two groups of adolescents with first episode psychosis: a) schizophrenia and b) non-schizophrenia patients. The structured neurological evaluation scale (NES) was administered to 24 adolescents with first episode psychosis. The number of NSS, the total and subscales scores were correlated with age in patients and in 39 healthy controls. Adolescents with first-episode psychosis had a higher prevalence of NSS than healthy controls; the schizophrenia patients (N=9) scored higher than non-schizophrenia patients (N=15). The number of NSS, total score and the scores on three of the four NES subscales correlated inversely with age in the healthy control group. No correlation was found for the schizophrenia group. For the non-schizophrenia group, a significant negative correlation was found only in one subscale. The decrease of NSS during adolescence in the healthy population but not in the patient groups with psychosis may be an indicator of a disturbance of brain processes that occurs during development. We did not find a clear pattern of NSS that distinguished schizophrenia from other psychoses.
منابع مشابه
نرمنشانههای عصبی در بیماران دچار نخستین دوره سایکوز، بستگان درجه اول آنها و افراد سالم
Abstract Objectives: This study aimed to evaluate and compare neurological soft signs (NSS) in patients with first episode psychosis, in their first-degree relatives, and in healthy control subjects. Method: Thirty patients with first-episode psychosis, 30 of their first-degree relatives, and 30 healthy controls were evaluated by the Structured Clinical Interview for DSM-IV (SCID) for p...
متن کاملA Study of Soft Neurological Signs and Its Correlates in Drug-Naive Patients with First Episode Psychosis
BACKGROUND Soft neurological signs are minor, non localizing, objective abnormalities, thought to reflect damage in cortical and sub-cortical connections or connections within different cortical regions. Regional structural grey matter anomalies have already been observed and correlated with the presence of cognitive deficits and presence of soft neurological signs in schizophrenic patients. ...
متن کاملThe 2-year stability of neurological soft signs after a first episode of non-affective psychosis.
We examined the 2-year stability of neurological soft signs (NSS) in 29 patients after a first episode of psychosis. The numbers of NSS at inclusion and at 2 years follow-up were similar, but there was a significant increase in the numbers of NSS in the sub-group of patients whose dosage of antipsychotic medication had increased over time.
متن کاملNeurological abnormalities and cognitive ability in first-episode psychosis.
BACKGROUND It remains unclear if the excess of neurological soft signs, or of certain types of neurological soft signs, is common to all psychoses, and whether this excess is simply an epiphenomenon of the lower general cognitive ability present in psychosis. AIMS To investigate whether an excess of neurological soft signs is independent of diagnosis (schizophrenia v. affective psychosis) and...
متن کاملAbnormal movements in first-episode, nonaffective psychosis: dyskinesias, stereotypies, and catatonic-like signs.
Motor abnormalities represent a neurobehavioral domain of signs intrinsic to schizophrenia-spectrum disorders, though they are commonly attributed to medication side effects and remain understudied. Individuals with first-episode psychosis represent an ideal group to study innate movement disorders due to minimal prior antipsychotic exposure. We measured dyskinesias, stereotypies, and catatonic...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The British journal of psychiatry : the journal of mental science
دوره 195 3 شماره
صفحات -
تاریخ انتشار 2006